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To interoperate with different APIs which support different gene identifier schemes. We'll first use mygene.info to resolve gene identifiers.
With the Entrez Gene ID, we can resolve lots of different identifiers and identifiability information from mygene.info.
An appyter was built for performing Gene Centric signature reverse searches against the LINCS data. Its functionality is repeated here.
https://www.mousephenotype.org/
IMPC contains serves mouse phenotype information associated with gene markers. Its API is described here and allows us to identify phenotypes significantly associated with a gene.
https://ldh.clinicalgenome.org/ldh/ui/
The exRNA Linked Data Hub (LDH) facilitates efficient access to collated information such as links and select data from different data sources, which are made available using RESTful APIs. Currently, LDH focuses on linking information about human genes and variants to support exRNA curation efforts.
We provide the gene symbol to exRNA and obtain the reported linked data. The query will produce a document with all associated regulatory element in the +/- 10kb range or overlapping the gene.
We query IDG's knowledge base of targets and their Disease associations through the Pharos API.
We query the Harmonizome API for associations with various biological entities in a standardized set of numerous omics datasets, as detailed here.
https://www.uniprot.org/
UniProt is a comprehensive database on protein function information. Their Proteins REST API, documented here, can be used for gene-centric queries.
https://www.ebi.ac.uk/proteins/api/genecentric?offset=0&size=100&gene=STAT3